Compulsive hand washing? MisinformationKills. $1M reward: Do we need more data re: Fluvoxamine for COVID-19? People who report not tolerating the drug are typically prescribed too high a dose. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. P-value was 10^-14 on that study (done by Dr. The track management was so impressed, they asked for prescriptions. There were no studies reported out so far where fluvoxamine made things worse or neutral. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. Substitutions. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). Paper reviewing the evidence and mechanisms of action for fluvoxamine: Lenze Phase 2 RCT published Nov 12, 2020: Seftel RWE trial that confirmed the Phase 2 trial published Feb 1, 2021. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. He has a history of giving away some of his millions to good causes, and when COVID-19 began. Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. In other cases, stop cold turkey. In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. So it was both obvious and convincing the difference between the groups to the workers and the track management. Hes now outlived his initial prognosis by several years. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. Avoid caffeine, benadryl, tylenol, and alcohol. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for, because they were rejected by 10 journals. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. All can merit a fluvoxamine prescription based on traditional diagnoses. . Steve Kirsch. While Fauci was crafting national pandemic policies, Fauci's wife [Christine Grady, Chief Bioethicist, NIH] was back stopping [them]." Report coming soon. Timing is everything with respect to outcomes. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. Dosage there is 30mg once a day. He may not be a good scientist, but hes smart, says WVUs Feinberg. Fluvoxamine has a 40 year safety track record. has tons of info on fluvoxamine with all the links. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. Its motivated out of his sense of keeping people safe and advancing health care.. Most recent articles first. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. O, Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19 | Blood Advances | American Society of Hematology, Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Fluvoxamine for COVID-19 Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Drug Repurposing Research Leads to Potentially Game-Changing Treatment to Prevent Clinical Deterioration in Outpatients With COVID, The Covid-19 Early Treatment Fund was launched to provide funding for research in order to, Steve Kirschs answer to What is the current treatment for Covid-19? To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. The NIH wrote a bullshit rejection because the FDA told them not to approve it. See my article on treatments. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. ). If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. Its sad, but its true, he told me. As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. Doctors who are most familiar with the drug would prescribe it to their patients. just like ivermectin). I fixed the link to the fluvoxamine article. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. So much for evidence-based medicine. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults. Things took a final and dramatic turn once Kirsch started claiming the government was covering up vaccine deaths. Hes also recently increased the number of Americans he claim have been killed by the vaccine from 25,0000, to 150,000, or even as many as 250,000 Americans. I only know of a few doctors who prescribe this off-label, all with 100% success rates. It cant be more clear than this. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. But the whole process has gone too slowly for Kirsch. Try refreshing this page and updating them one In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. Theyre finding alternative leaders to follow, Morris said. . They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. The infectious disease scientists lied to me. All can merit a fluvoxamine prescription based on traditional diagnoses. Steve calls himself a "medical philanthropist" who says "the most important thing to me is saving lives." In . This looks ominous, but it harmless. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. The medical community doesnt care about saving lives. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? Medicine today isnt about saving your life. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? It has shown to be 100% protective of hospitalization in 2 clinical trials. With cases spiking, the Los Angeles area banned gatherings. . . This post was written to memorialize the corruption. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. The paramedics will think you are on drugs. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Fluvoxamine (Luvox) is a Selective Serotonin Receptor Inhibitor (SSRI) that is clinically indicated for OCD in children, and can be used off label for depression. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. In November, CETF gave the group an additional $500,000 for a phase 3 clinical trial that might show conclusive proof of efficacy. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. Quick Summary . In other cases, stop cold turkey. . Reason is the hospital gets release from liability if they follow NIH guidelines. This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). [4] Steve Kirsch - Silicon Valley Philanthropist Shares Review of CDC Data: COVID-19 Vaccine Associated with 100X Deaths Compared to Influenzas [5] Steve Kirsch - FOIA Document for Vaccine Discussion as to mRNA-based Vaccine Safety Signals Added 12th August 2021: They knew in advance it was coming and on the day the paper was published they ignored it entirely. That way you can start immediately. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. The NIH wrote a bullshit rejection because the FDA told them not to approve it. The FDA approved Molnupiravir which was less effective. Those who know Kirsch say this is a typical tactic. I believe they made the right decision and we should be rushing to follow their advice. There is no evidence fluvoxamine is harmful and led to a worse outcome. I see it all the time on social media, Morris told me. While combining the results of several well-designed trials can strengthen an argument or unearth patterns unseen in smaller samples, a meta-analysis is just the sum of its parts; any single well-done experiment is more useful than combining the results of several poorly done ones. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. He's founded 7 companies, 2 with billion dollar valuations. Get your prescription in advance of getting COVID. And, according to three members of CETFs scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for covid. MD, MPH; Steven C. Marcus, PhD. Last Checked: 03/02/2023. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. . The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. If you continue to get this message, The web price charge of skirsch.io . So you can address your OCD and if you get COVID, youll can up the dose. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. I took it myself at that dosage and noticed zero side effects. That receptor also helps regulate the body's . Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. Most doctors wont use it until NIH greenlights it, no matter what the science says. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora After boosting unproven covid drugs and campaigning against vaccines, Steve Kirsch was abandoned by his team of scientific advisersand left out of a job. Comparison with molnupiravir. One Silicon Valley entrepreneur thought he could beat the odds. . This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. Some people report mild nausea while on the drug (stops when stop the drug). The combined p value of the two studies is <.0001. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. this is NOT about the science. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. The man who ran Risperdal sales, Alex Gorsky, is now CEO of Johnson & Johnson. An approach that promised to democratize design may have done the opposite. 9th International Congress on Psychopharmacology 5th International Symposium on Child and Adolescent Psychopharmacology (One of them, Eric Lenze, was in fact giving a presentation on fluvoxamine to the National Institutes of Health the next day.) The web value rate of skirsch.io is 2 . Everyone says "we need more data" to show fluvoxamine works for COVID. With covid, 80% of your patient population does just peachy with no treatment at all, just a little bed rest and fluid. It used to be that a Phase 3 study would do it. I bumped up the reward to $1M. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. No more. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. We look for advances that will have a big impact on our lives and break down why they matter. . The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. . A very short op-ed arguing for using fluvoxamine against COVID. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. Di scl ai mer: T he vi ews expressed i n t hi s art i cl e are my own personal opi ni on based on my 1, 000+ hour st udy of cut t i ng edge . Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here.. Here are the key things you should know about fluvoxamine for COVID: It works. I have all of these on hand and I load up on vitamin D3 every day. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. I have all of these on hand and I load up on vitamin D3 every day. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). He started a covid-19 vaccine company. He was recently featured on 60 Minutes which highlighted his . Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. Their willingness to lie did. She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Dr. Eric Lenze: So the results were really pretty. So why would we wait when lives are being lost? This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. Worst case, if we ignore all additional evidence so the average is a 60% pass rate. Items included in the Television News search service. It works best when it is given early, as soon as symptoms start. We should be making decisions now based on the evidence on the table today. One of the drugs, Fluvoxamine, showed a 30 . Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Over the summer, the conflict reached his most recent startup, M10. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. Once the Phase 2 result came out, it should have been embraced by doctors. The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. Skirsch.io Steve Kirsch Home page Fluvoxamine, COVID, pandemic, . Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). Keeping this drug off the NIH Guidelines does nothing to reduce the death rate. Most recent articles first. From the French observational data (see the very last page), it appears that the biggest effect is limiting serotonin release (any SSRI will do that). He is very smart, and knows that he is very smart, and sometimes he behaves like he thinks he's the smartest guy in the room, whether he is or isn't., Kirschs response was to take his name off articles hed written about vaccine deaths, changing the authorship to VaccineTruth., On July 1, he tweeted from his personal account, My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. The anecdotal data of 100% success rates is further icing on the cake. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 1.15K 'This Has Cost Millions of Lives': Steve Kirsch on Suppression of Repurposed Drugs and a Spike in Deaths 5 Months After Vaccine Rollout American Thought Leaders AMERICAN THOUGHT LEADERS JAN JEKIELEK Show more Loading comments. I must admit that this is an anniversary that snuck This is why Cliff doesnt talk to me. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). Discover special offers, top stories, But a panel of key opinion leaders from the NIH, CDC . His latest startup, M10, is a spin-off of a spin-off that sells a blockchain for banks. Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for Read More The best COVID treatments for hospitalized patients Seven treatments for hospitalized COVID patients with very high success rates. May 16, 2022. Summary of key evidence. Fluvoxamine, COVID, pandemic, . It could do nothing. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. A video presentation by Steve Kirsch, Executive Director of the Covid-19 Early Treatment Fund. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. Eventually, a press representative who was listening in, David Satterfield, unmuted his microphone to suggest we finish our conversation by email. It was not compatible with his position as CEO to continue taking a very public stance on the vaccines, Richard Char, M10s general counsel, told me. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. What happens when your prescription drug becomes the center of covid misinformation. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group.