Since the vast majority of Equine Asthma patients do not have a histamine-associated problem, this isn't likely to work for most. Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. Cyclosporine, which is approved for the treatment of canine atopic dermatitis, has an onset of efficacy of up to 4 weeks. Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including environmental allergies, food allergies, flea allergy, and contact allergies. For dogs weighing between 10 and 14.9 pounds, give of a 5.4 mg tablet twice daily as dosage. This product came to the market in the US in Fall 2020. Vet Dermatol 2013;24(5):479-e114. But you're making a deal with the devil when you use these . Vet Dermatol 2019;30(2):87-90. Generally self-limiting and harmless, hives are nonetheless uncomfortable and can occasionally lead to angioedema (swelling under the skin) or purpura (blood vessels rupturing and leaking blood internally). Adding an update here in case its helpful for others. Also. No texts please., Horse breeding from planning through foal care, Horse-health-problem risk factors, prevention, diagnosis, and treatment, Design and maintain a healthy horse operation, Prevention and treatment for problems of the equine foot, How to care for the basic health needs of horses, Prevention, diagnosis, and treatment of leg lameness, Proper feeding practices for foals, adult horses, and older horses, All aspects of caring for performance horses, News and issues for equine health professionals, Discussions about the welfare of our equine friends. Use code GOODRX20 Sponsored by Its kind of cumbersome, but I have two on it, and they are doing better. 7. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . Apoquel tablets are scored to be halved to ensure that the ingredients are equally distributed. We have had variable results with this treatmet. My Docs are among the first in the country to use this drug on itchy and wheezy horses. Your veterinarian also may use dexamethasone in high doses in emergencies for anaphylactic reactions, spinal cord trauma or shock. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. Apoquel is an anti-itch tablet given twice daily for the first . Commonly prescribed for: Manage inflammation in diseases or conditions in which the immune system has a significant role, Therapeutic Class: Synthetic Corticosteroid Hormone. Log in to browse, order and prescribe from our compounded drugs formulary. As a result, muscles relax and cause heavy sedation, notes DailyMed. 19. If she stays the way she is now, I will play with spacing it out furtherfirst with every 2 days. The American company "Zoetis Inc" created the drug Apoquel, which deservedly occupies a leading position among drugs for eliminating itching in dogs, regardless of its etiology. 15. Apoquel has been a game changer, however. Six adult horses with a mean weight of 528 kg were administered a single dose of 0.5 mg/kg oclacitinib maleate. Horse dosing is 5 pills. Log in to fill, refill or renew the medication prescribed by your veterinarian. Acupuncture: It appears that some horses with Equine Asthma can benefit from acupuncture to help with breathing function. Ortalda C, Noli C, Colombo S, et al. The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Apoquel is a prescription dog allergy medicine used for the control of itch associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months and older. 13. Vet Dermatol 2017;28(5):512-e123. Loft K, Simon B. You can use a nebulizer, an inhaler, or a single-nostril aerosol chamber. While efficacy was comparable to that observed in the previous studies, significant positive effects on the dogs quality of life were observed in >91.5% of cases after 630 days. Im hopeful, however, that I will be able to stretch out more so that Im looking at $250 across 8-10 weeks instead. Minimum order 6 tablets per dosage. Right now he is on an Aservo Inhaler but I dont see any improvement and he is getting real tired of the application process. Unlike steroids, the drug has minimal impact on the immune system. Every cough means something is a common saying among equine veterinarians. Diphenhydramine can alter the results of skin allergy testing; discontinue this medication at least 2 weeks before testing. Ive used it on a couple of mine, and I also have some friends who have done it. 13. 27. Freedom of Information Summary NADA 141-345 The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. Apoquel comes in tablet form only. Cosgrove SB, Wren JA, Cleaver DM, et al. Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Typically, a few sessions are required. Little PR, King VL, Davis KR, et al. We cannot be sure of accurate dosing when tablets are quartered, and thus this practice is not recommended. Researchers have proven flaxseed reduces skin lesions in IBH horses (ONeill et al., 2002). In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). IgE binds to cells in the body and releases inflammatory molecules. Apoquel (oclacitinib tablet) Dosing & Administration How to dose Apoquel 0.4-0.6 mg/kg (0.18-0.27 mg/lb) Twice daily (BID) for up to 14 days Continue therapy once daily (SID) thereafter for maintenance May be given with or without food May discontinue without tapering Apoquel Dosing Guide Weight Range (lb) Number of Tablets to be Administered Download Apoquel Information Sheet. Qualifies for Zoetis Petcare Rewards! Maintaining Your Horses Weight During the Winter, Special Report: Preventing 3 Common Equine Joint Issues, JACKSON- Gelding/Bay/Mustang (Nevada) - Project/Ready for Training, JENNINGS Gelding/Cremello/Mustang (BLM) Ridable (Green), recent study evaluating almost 400 potential allergens, BONNIE: Sorrel Mustang Mare Non-Riding Companion Only. In more severe cases, Apoquel can be given twice per day. Copyright 2023 Today's Veterinary Practice Web DesignbyPHOS Creative. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Gonzales AJ, Bowman JW, Fici GJ, et al. Apoquel is sold per tablet in strengths of 3.6 mg, 5.4 mg, or 16 mg. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. Please select your state below. This includes dietary supplements, shampoos, liniments, fly sprays, coat conditioners, etc. Im glad that youve found a solution- but, after the allergy testing you can start them on a regimen designed exactly for what they are allergic to, which will help to desensitize them to those allergens. K. Route of Administration . He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. So I want to make sure she has the support she needs to acclimate to hot humid summer weather. Less common side effects include diarrhea, vomiting, lack of appetite, dry mouth and mild straining to urinate. She gets it all year long since she has a full list of allergies including dust, feathers, and cat dander along with grasses. 18. The innovative formula of the drug allows you . 20. Bursatti, Leeches) in Dogs, Cats and Horses. The powerful network of cells and antibodies known as the immune system can recognize dangerous invaders and disarm them before they hurt the host. Most common side effects are vomiting and diarrhea. 21. Assuming you cannot contact your vet: For hives or possible allergic airway disease (heaves), for a 1000 lb horse, give 5-10 tabs of 25mg diphenydramine crushed up and mixed in water and dosed in a syringe orally (by mouth). 16. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. APQ-01043R3, halved to ensure that the ingredients are equally distributed. Apoquel should not be used in breeding, pregnant, or lactating dogs. Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. Panteri A, Strehlau G, Helbig R, et al. There are two types of this condition, summer-pasture-associated and classic recurrent airway obstruction (RAO). The dose of Apoquel is 0.4-0.6 mg/kg every 12 hours for up to 14 days, then 0.4-0.6 mg/kg once daily thereafter. 2. Vet Dermatol 2014;25(6):512-518. And I am debating spreading even further to every 2 days to see how she does, but I am a bit nervous to do so, especially when its so hot. If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control. If your horses allergies are seasonal, talk to your veterinarian about steps you can take to stay ahead of them. Dexamethasone commonly is used in horses to treat allergic reactions such as respiratory allergies, chronic obstructive pulmonary disease (heaves), hives, itching and inflammatory diseases including arthritis. These reports suggest the potential use of oclacitinib in other diseases; however, it cannot be stressed enough that the use of oclacitinib in these diseases is an off-label use.